From a total of 622 potential studies, six in vivo studies assessing the use of cannabinoids for treatment of melanoma were deemed eligible for the final analysis. Systematic searches were carried out in PubMed, Embase, Scopus, and ProQuest Central databases for relevant articles published from inception. Therefore, the aim of this study was in the first instance to review the evidence from in vivo studies on the effects of cannabinoids on melanoma. Despite prohibited use of Cannabis in most parts of the world, in recent years there have been renewed interests in exploiting the beneficial health effects of the Cannabis plant-derived compounds.

plant, can reduce cell proliferation and induce apoptosis in melanoma cells.

Several studies have shown that “cannabinoids”, the major compounds of the Cannabis sativa L. While there has been substantial progress in the treatment of cancer in general, malignant melanoma, in particular, is resistant to existing medical therapies requiring an urgent need to develop effective treatments with lesser side effects. (And for people who do get infected and are at higher risk of severe illness, a gradually increasing supply of anti-COVID drugs like Paxlovid is another option.) Vaccines are certainly not as novel a preventive treatment as cannabis, but the reams of data on their efficacy and safety mean they're by far your best bet.Melanoma is the fourth most common type of cancer diagnosed in Australians after breast, prostate, and colorectal cancers. In the meantime, COVID-19 vaccines and boosters remain the best frontline medical defenses against severe illness, hospitalization, and death. It's possible that COVID-19 prevention will become another burgeoning area of research here-we simply don't know enough yet. Medical marijuana- which has been shown to be effective for conditions like chronic pain-is a booming area of research, and scientists are currently studying a number of cannabis compounds for their potential application in treating or preventing a wide variety of medical issues. However, it's worth noting that just as we can't say that this study shows cannabis protects people from COVID-19, we also can't say that cannabis has no medicinal value here. “I don't think many molecules at that level actually pan out into functional medicines.” (One question, for instance, is how much of the compounds would a person need to ingest in order to make them bio-available for fending off coronavirus invaders.) “This is a long way off, assuming they work, which is by no means guaranteed,” he added. “These compounds would need to be tested in animals, then in humans, and actually demonstrated to be effective against COVID,' Dr. Peter Grinspoon, M.D., a physician at Massachusetts General Hospital, instructor at Harvard Medical School, and medical cannabis consultant, issued a similar note of caution. As of now, we simply can't say whether cannabidiolic acid or cannabigerolic acid will actually help prevent infection with the SARS-CoV-2 virus, Dr. “What happens in a test tube does not always translate into what happens in animals or humans,” as Patricia Frye, M.D., an integrative medicine practitioner and cannabis expert who teaches at the University of Maryland School of Pharmacy, told Forbes. There are a lot of steps in between making these particular lab findings and drawing the conclusion that cannabis prevents COVID infections in the real world. Just because a compound shows promise in a laboratory experiment conducted on isolated cells does not mean that it would work the same way in actual humans. So does that mean cannabis could help prevent COVID?

These results “clearly indicate that CBDA and CBGA are both able to block cell entry by SARS-CoV-2,” the authors write. Next, they exposed human epithelial cells-the technical term for the surface tissue that covers all internal and external surfaces of the human body-to this cannabinoid-virus mixture.Īfter 24 hours, researchers looked for viral RNA-evidence of the virus getting inside the human cells-and found none. After some predictive computer modeling of chemical interactions between the the spike protein and these compounds, the researchers incubated the live SARS-CoV-2 virus (as well as a pseudovirus expressing the SARS-CoV-2 spike protein) with each of the compounds as well as a control compound.

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